However, this is not the same as Alzheimer’s disease or irreversible dementia.
That said, long-term use of certain medications has shown an association (not proven causation) with increased dementia risk in observational studies — which means researchers see a pattern, but other factors may be involved.
8 Medication Classes Linked to Cognitive Changes (With Context)
Below are medications that have appeared in studies exploring brain health. This list is meant to inform — not scare or suggest stopping any drug without medical advice.
1.
Anticholinergics (Long-Term Use)
Diphenhydramine (Benadryl®), Oxybutynin (for overactive bladder), Some antidepressants (e.g., amitriptyline)
Multiple studies, including one from
JAMA Internal Medicine
, found a link between heavy long-term use and higher dementia risk. These drugs block acetylcholine — a key brain chemical for memory.
2.
Proton Pump Inhibitors (PPIs)
Omeprazole (Prilosec®), Pantoprazole (Protonix®)
Some observational studies show an association with dementia — possibly due to vitamin B12 deficiency, magnesium loss, or direct neurological effects. But no clinical trials prove causation.
